You're probably already familiar with VSCO from their film presets, but they just released a keyboard shortcut tool for Lightroom that might change the way you handle your workflow in a more powerful way.
VSCO Keys is a "powerful keyboard shortcut tool created to drastically reduce image editing time in Adobe Lightroom 4 and Lightroom 3." It accomplishes this by actually taking control of your keyboard and re-assigning every key to a shortcut. The tool comes with two standard layouts, plus you can actually use their web tool to create your own custom layouts. It runs as a little background utility and when you're in Lightroom and want to activate it, you just hit ESC and it flips they keyboard over to your shortcuts. Another hit of the ESC key brings you back to the standard keyboard layout. It's also pretty smart in that if you switch to another program besides Lightroom, it switches off; then back on again when you switch back to Lightroom.
Unfortunately, the product is only offered for Lightroom and I haven't found any information about it being worked on for other editing software. They're currently offering a free 14 day trial and if you've already purchased their film packs, you'll get 25% off the purchase. I've been using it for a few edits now and it has definitely sped up my workflow, although I'm still getting used to it so hopefully it will only improve my process more over time.